Endocrine Abstracts

Introduction: In the pediatric population the progression of obesity-related diseases can be delayed or prevented through changes in lifestyle, including the promotion of a Mediterranean-like dietary (MD) pattern.Objective: We aimed to assess the efficacy of an educational training to MD based on gamification with respect to a conventional weight-loss treatment in obese pediatric subjects on weight decreased and cardiometabolic risk factors (GOOD-DAY Tri...

IntroductionIn the pediatric population, the progression of obesity-related diseases can be delayed or prevented through lifestyle changes, including the promotion of a Mediterranean-like dietary (MD) pattern.ObjectiveWe aimed to evaluate the gut microbiome ecology in relation to dietary and clinical parameters in the pediatric subjects with obesity recruited at baseline in a protocol on an educational traini...

ContextGenetic obesity, including syndromic and non-syndromic forms, represent a minority of cases but gene dysregulations make their management particularly difficult. Among them, Beckwith–Wiedemann syndrome (BWS) is a multisystem human genomic imprinting disorder characterized by overgrowth, macroglossia, abdominal wall defects, hemi hyperplasia, enlarged abdominal organs, and an increased risk of embryonal tumours. The syndrome is caused by genet...

BackgroundIn lipodystrophy (LD) adipose tissue function is impaired, leading to a severe metabolic syndrome. Familiar Partial LD (FPLD) type I (Kobberling Syndrome) overlaps with Cushing’s syndrome phenotype. The latter and the metabolic impairment observed in FPLD1 may suggest a crosstalk between the HPA axis, assuming that leptin sensitivity is preserved in this context. We aimed to evaluate if leptin levels are associated with glucocorticoid acti...

Background: The increase of global childhood obesity has led to an increase of associated co-morbidities also at a young age. The pro-inflammatory state and insulin resistance are two master regulators of several complications, including hypertension and pre-diabetes frequently connected in a complex cross-talk.Aim: To evaluate the relationship between glucose alterations and blood pressure and the pathogenetic involvement of the renin-aldosterone system...

Background: The relationship between composition and function of microbiota, obesity and nutrition has been increasingly studied and is still a challenge.Aims: To test whether in a group of 12 pediatric patients with obesity the treatment with a structured hospital and in-home Mediterranean Diet intervention had an impact on gut microbiota composition, function, and metabolite production, including Short chain fatty acids (SCFAs).M...

Introduction: Lipodystrophy syndromes are characterized by a progressive metabolic impairment secondary to adipose tissue dysfunction and genetic background. The role of microbiota is still uninvestigated.Objective: Evaluate the gut microbiome ecology in relation to dietary and clinical parameters in two infant siblings with congenital generalized lipodystrophy type 4 (CGL4) before and after treatment with recombinant leptin.Method...